Dioscorea japonica is a species of yam that is used for food. The root has a very pleasant mild flavor with a floury texture and is commonly eaten as a potato substitute. Active compounds in D. japonica are reported to exert various biological effects, including anti-rheumatic and anti-oxidant activities. According to the in vitro experiment results, Ma Extract, containing the root extract of D. japonica, is a multi-functional ingredient displaying anti-wrinkle, anti-oxidant, and anti-allergic actions. Ma Extract was tested clinically and show a moisturizing effect.